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 Cell-cell adherens

Page updated 19/2/03

Cell-cell adherens junctions are just one adhesion type others include the desmosome and focal contact.  Cell-cell adherens attach the actin filament system from one cell to that of a neighbouring cell. Like the focal contact,  the adherens junction also performs signalling functions.

Focal Contact   Wnt signalling  

Figure 1.  Cell-cell adherens - The main structural components
Protein Function Reference
a-actinin An F-actin bundling protein  
ADIP An afadin and a-actinin binding protein Asada et al, 2003
Afadin   Mandai et al, 1997
ZO-2   Itoh et al, 1999
Table 1   Cell -cell Adherens Junction Proteins


Asada, M., Irie, K., Morimoto, K., Yamada, A., Ikeda, W., Takeuchi, M. & Takai, Y. (2003) ADIP, a novel afadin- and a-actinin-binding protein localized at cell-cell adherens junctions., J.Biol.Chem. 278, 4103-4111.

Fannon, A. M., Sherman, D. L., Ilyina-Gragerova, G., Brophy, P. J., Friedrich jr, V. L. & Colman, D. R. (1995) Novel E-cadherin-mediated adhesion in peripheral nerve: Schwann cell architecture is stabilized by autotypic adherens junctions. J.Cell Biol. 129, 189-202.

Guvakova, M. A., Adams, J. C. & Boettiger, D. (2002) Functional role of {alpha}-actinin, PI 3-kinase and MEK1/2 in insulin-like growth factor I receptor kinase regulated motility of human breast carcinoma cells. J Cell Sci. 115, 4149-4165.

Hunter, C., Sung, P., Schejter, E. D. & Wieschaus, E. (2002) Conserved domains of the Nullo protein required for cell-surface localization and formation of adherens junctions. Mol.Biol. Cell. 13, 146-157.

Itoh, M., Morita, K. & Tsukita, S. (1999) Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and a-catenin.  J.Biol.Chem. 274, 5981-1986.

Krendel, M., Gloushankova, N. A., Bonder, E. M., Feder, H. H., Vasiliev, J. M. & Gelfand, I. M. (1999) Myosin-dependent contractile activity of the actin cytoskeleton modulates the spatial organization of cell-cell contacts in cultured epitheliocytes. PNAS. 96, 9666-9670.

Krendel, M. F. & Bonder, E. M. (1999) Analysis of actin filament bundle dynamics during contact formation in live epithelial cells. Cell Motility Cytoskeleton. 43, 296-309.

Mandai, K., Nakanishi, H., Satoh, A., Obaishi, H., Wada, M., Nishioka, H., Itoh, M., Mizoguchi, A., Aoki, T., Fujimoto, T., Matsuda, Y., Tsukita, S. & Takai, Y. (1997) Afadin: A novel actin-filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J. Cell Biol. 139, 517-528.

Ohtsuka, T., Nakanishi, H., Ikeda, W., Satoh, A., Momose, Y., Nishioka, H. & Takai, Y. (1998) Nexilin: A novel actin filament-binding protein localized at cell-matrix adherens junction.  J.Cell Biol. 143, 1227-1238.

Rüdiger, M. (1998) Vinculin and a-actinin: shared and unique functions in adherens junctions. BioEssays. 20, 733-740.

Sahai, E. & Marshall, C. J. (2002) ROCK and Dia have opposite effects on adherens junctions downstream of Rho. Nature Cell Biol. 4, 408-415.

Takahashi, K., Nakanishi, H., Miyahara, M., Mandai, K., Satoh, K., Satoh, A., Nishioka, K., Aoki, J., Nomoto, A., Mizoguchi, A. & Takai, Y. (1999) Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain-containing Protein. J. Cell Biol. 145, 539-549.

Takai, Y. & Nakanishi, H. (2003) Nectin and afadin: novel organizers of intercellular junctions. J Cell Sci. 116, 17-27.

Tsukita, S., Hieda, Y. & Tsukita, S. (1989) A New 82-kD Barbed End-capping Protein (Radixin) Localized in the Cell-to-Cell Adherens Junction: Purification and Characterization. J.Cell Biol. 108, 2369-2382.

Waterman-Storer, C. M., Salman, W. C. & Salman, E. D. (2000) Feedback interactions between cell-cell adherens junctions and cytoskeletal dynamics in newt lung epithelial cells. Mol.Biol.Cell. 11, 2471-2483.

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