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Other Proteins that contain the ADF homology domain.

A number of other actin binding proteins with properties distinct from the ADF/Cofilin family exist (Table 1).
Protein Function References
Abp1p A mulitfunctional protein involved in the Golgi cytoskeleton, endocyotosis and Arp2/3 activation. Goode et al, 2001; Holtzman et al, 1993; Jeng & Walsh 2001
Coactosin A protein originally discovered in yeast but now found in humans where it binds 5-lipoxygenase de Hostas et al, 1993; Provost et al 2001a & b.
Drebrin A group of 95- 100kDa actin-binding proteins that are especially enriched in brain Hayashi et al, 1999; Peitsch et al, 1999.
Twinfilin An actin monomer sequestering protein that contains two ADF homology domains. Goode et al, 1998; Palmgren et al, 2001, 2002; Wahlstrom et al, 2001.
Table 1 Other proteins that contain the ADF homology domain

de Hostas, E. L., B. Bradtke, et al. (1993). “Coactosin, a 17 kDa F-actin binding protein from Dictyostelium discoideum.” Cell Mot.Cytoskeleton 26, 181-191.

Goode, B. L., Drubin, D. G. & Lappalainen, P. (1998) Regulation of the cortical actin cytoskeleton in budding yeast by twinfilin, a ubiquitous actin monomer sequestering protein. J.Cell Biol. 142, 723-733.

Goode, B. L., Rodal, A. A., Barnes, G. & Drubin, D. G. (2001) Activation of the Arp2/3 complex by the actin filament binding protein Abp1p. JCB. 153, 627-634.

Hayashi, K., R. Ishikawa, et al. (1999). Domain analysis of the actin-binding and actin-remodeling activities of drebrin. Exp.Cell Res. 253, 673-680.

Holtzman, D. A., Yang, S. & Drubin, D. G. (1993) Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae. J.Cell Biol. 122, 635-644.

Jeng, R.L. & Welsh, M.D. (2001) Cytoskeleton: Actin and endocytosis- no longer the weakest link. Current Biology 11, R691-R694

Palmgren, S., Ojala, P. J., Wear, M. A., Cooper, J. A. & Lappalainen, P. (2001) Interactions with PIP2, ADP-actin monomers, and capping protein regulate the activity and localization of yeast twinfilin. J. Cell Biol. 155, 251-260.

Palmgren, S., Vartiainen, M. & Lappalainen, P. (2002) Twinfilin, a molecular mailman for actin monomers. J. Cell Sci. 115, 881-886.

Peitsch, W. K., C. Grund, et al. (1999). "Drebrin is a widespread actin-associateing protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells." Eur.J.Cell Biol. 78, 767-778.

Provost, P., Doucet, J., Hammarberg, T., Gerisch, G., Samuelsson, B. & Radmark, O. (2001a) 5-Lipoxygenase interacts with coactosin-like protein., J. Biol.Chem. 276, 16520-16527.

Provost, P., Doucet, J., Stock, A., Gerisch, G., Samuelsson, B. & Radmark, O. (2001b) Coactosin-like protein, a human F-actin-bining protein: critical role of lysine-75. Biochem. J. 359, 255-263.

Wahlstrom, G., Vartiainen, M., Yamamoto, L., Mattila, P. K., Lappalainen, P. & Heino, T. I. (2001) Twinfilin is required for actin-dependent developmental processes in Drosophila. J.Cell Biol. 155, 787-795.

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