|Ono, S. (2002) Function of
ADF/cofilin in muscle cells: an important regulator of actin
cytoskeletal dynamics in myofibril assembly and muscle disease. in Recent
Developments in Cell Research, Kerala, India.
muscle cells, the actin cytoskeleton is differentiated into myofibrils
that are specialized contractile apparatuses. To assemble and maitain
myofibrils, a specific regulatory mechanism of actin filament dynamics
is required. The actin depolymerizing factor (ADF)/cofilin proteins are
ubiquitous regulators of actin turnover among eukaryotes. However,
muscle-specific ADF/cofilin isoforms are present in several species and
play important roles in actin organization in muscle cells. This review
describes the function of ADF/cofilin as an important regulator of
myofibril assembly and muscle disease.