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ADF/Cofilin in Disease

In the organisms where it has been possible to test, ACs have been found to be vital.  No mutations have yet been associated with human disease but members of the AC family have been implicated in human disease. Both ADF and cofilin are associated with Hirano bodies, actin-rich rods present in neuronal cells of Alzheimer's patients and other neuro-degenerative diseases (Maciver & Harrington, 1995).  Similar cofilin-rich structures appear in the cytoplasm of cultured hippocampal cells when treated with neuro-degenerative stimuli (Minamide et al, 2000).


Maciver, S. K. & Harrington, C. R. (1995) Two actin-binding proteins, actin depolymerizing factor and cofilin, are associated with hirano bodies, Neuroreport. 6, 1985-1988.

Minamide, L. S., Streigl, A. M., Boyle, J. A., Meberg, P. J. & Bamburg, J. R. (2000) Neurodegenerative stimuli induced persistent ADF/cofilin-actin rods that disrupt distal neurite function., Nature Cell Biol. 2, 628-636.

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