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The Arp2/3 complex


Amann, K. J. & Pollard, T. D. (2001) Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy. PNAS. 98, 15009-15013.

Blanchion, L., Pollard, T. D. & Mullins, R. D. (2000) Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks. Curr.Biol. 10, 1273-1282.

Blanchoin, L., Amann, K. J., Higgs, H. N., Marchand, J.-B., Kaiser, D. A. & Pollard, T. D. (2000) Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins. Nature. 404, 1007-1011.

Boldogh, I. R., Yang, H.-C., Nowakowski, W. D., Karmon, S. L., Hays, L. G., Yates III, J. R. & Pon, L. A. (2001) Arp2/3 complex and actin dynamics are requires for actin-based mitochondrial motility in yeast. PNAS. 98, 3162-3167.

Boujemaa-Paterski, R., Gouin, E., Hansen, G., Samarin, S., Le Clainche, C., Didry, D., Dehoux, P., Cossart, P., Kocks, C., Carlier, M. F. & Pantaloni, D. (2001) Listeria protein ActA mimics WASP family proteins: It activates filament barbed end branching by Arp2/3 complex. Biochemistry. 40, 11390-11404.

Cooper, J. A. & Schafer, D. A. (2000) Control of actin assembly and disassembly at filament ends. Curr.Op.Cell Biol. 12, 97-103.

Cooper, J. A., Wear, M. A. & Weaver, A. M. (2001) Arp2/3 complex: advances on the inner workings of a molecular machine. Cell. 107, 703-705.

Dayel, M. J., Holleran, E. A. & Mullins, R. D. (2001) Arp2/3 complex requires hydrolysable ATP for nucleation of new actin filaments. PNAS. 98, 14871-14876.

Duncan, M. C., Cope, M. J. T. V., Goode, B. L., Wendland, B. & Drubin, D. G. (2001) Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex. Nature Cell Biol. 3, 687-690.

Egile, C., Loisel, T. P., Laurent, V., Li, R., Pantaloni, D., Sansonetti, P. J. & Carlier, M.-F. (1999) Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by ARP2/3 complex and bacterial actin-based motility. J.Cell Biol. 146, 1319-1332.

Evangelista, M., Pruyne, D., Amberg, D. C., Boone, C. & Bretscher, A. (2001) Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast. Nature Cell Biol. 4, 32-41.

Flanagan, L. A., Chou, J., Falet, H., Neujahr, R., Hartwig, J. H. & Stossel, T. P. (2001) Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filament in human melanoma cells. J.Cell Biol. 155, 511-517.

Furuoka, M., Suetsugu, S., Miki, H., Fukami, K. & Endo, T. (2001) A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex complex activation independent of Cdc42. J.Cell Biol. 152, 471-482.

Goode, B. L., Rodal, A. A., Barnes, G. & Drubin, D. G. (2001) Activation of the Arp2/3 complex by the actin filament binding protein Abp1p. JCB. 153, 627-634.

Gournier, H., Goley, E. D., Niederstrasser, H., Trinh, T. & Welch, M. D. (2001) Reconstituion of huamn Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. Mol. Cell. 8, 1041-1052.

Higgs, H. N. (2001) Actin nucleation: Nucleation-promoting factors are not all equal. Curr. Biol. 11, R1009-R1012.

Hollien, J. (2002) A state-of-the-Arp structure. Nature Struct. Biol. 9, 11.

Hufner, K., Higgs, H. N., Pollard, T. D., Jacobi, C., Aepfelbacher, M. & Linder, S. (2001) The verprolin-like central (VC) region of Wiskott-Aldrich Syndrome Protein induces Arp2/3 complex-dependent actin nucleation. J.Biol.Chem. 276, 35761-35767.

Ichetovkin, I., Grant, W. & Condeelis, J. (2002) Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex. Curr.Biol. 12, 79-84.

Insall, R. H., Muller-Taubenberger, A., Machesky, L. M., Kohler, J., Simmeth, E., Atkinson, S. J., Weber, I. & Gerisch, G. (2001) Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis. Cell Motility Cytoskeleton. 50, 115-128.

 Jeng, R. L. & Welch, M. D. (2001) Cytoskeleton: Actin and endocyosis- no longer the weakest link. Current Biology. 11, R691-R694.

Jung, G., Remmert, K., Wu, X., Volosky, J. M. & Hammer III, J. A. (2001) The Dictyostelium CARMIL protein links capping protein and the Arp2/3 complex to type I myosins through their SH3 domains. J. Cell Biol. 153, 1475-1497.

Kalman, D., Weiner, O. D., Goosney, D. L., Sedat, J. W., Finlay, B. B., Abo, A. & Bishop, J. M. (1999) Enteropathogenic E.coli acts through WASP and Arp2/3 complex to form actin pedestals. Nature Cell Biol. 1, 389-391.

Le Clainche, C., Didry, D., Carlier, M. F. & Pantaloni, D. (2001) Activation of Arp2/3 complex by Wiskott-Aldrich syndrome protein is linked to enhanced binding of ATP to Arp2. J.Biol.Chem. 276, 46689-46692.

Lechler, T., Jonsdottir, G. A., Klee, S. K., Pellman, D. & Li, R. (2001) A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. J. Cell Biol. 155, 261-270.

Ma, L., Rohatgi, R. & Kirschner, M. W. (1998) The ARP2/3 complex mediates actin polymerization induced by the small GTP-binding protein cdc42. Proc.Nat.Acad.Sci. USA. 95, 15362-15367.

Machesky, L. M. & Gould, K. L. (1999) The ARP2/3 complex: a multifunctional actin organiser. Curr.Op.Cell Biol. 11, 117-121.

Machesky, L. M. & Insall, R. H. (1998) Scar1 and the related Wiskott-Aldrich syndrome protein WASP, regulate the actin cytoskeleton through the ARP2/3 complex.  Curr.Biol. 8, 1347-1356.

Madania, A., Dumoulin, P., Grava, S., Kitamoto, H., Scharer-Brodbeck, C., Soulard, A., Moreau, V. & Winsor, B. (Mol.Biol.Cell) The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex. Mol.Biol.Cell. 10, 3521-3538.

Marchand, J.-B., Kaiser, D. A., Pollard, T. D. & Higgs, H. N. (2001) Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. Nature Cell Biol. 3, 76-82.

May, R. C., Caron, E., Hall, A. & Machesky, L. M. (2000) Involvement of the Arp2/3 complex in phagocytosis mediated by FcgR or CR3.  Nature Cell Biol. 2, 246-248.

May, R. C., Hall, M. E., Higgs, H. N., Pollard, T. D., Chakraborty, T., Wehland, J., Machesky, L. M. & Sechi, A. S. (1999) The ARP2/3 complex is essential for the actin-based motlity of Listeria monocytogenes. Curr.Biol. 9, 759-762.

Miller, K. G. (2002) Extending the Arp2/3 complex and its regulation beyond the leading edge. J.Cell Biol. 156, 591-593.

Mullins, R. D. (2000) How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures. Curr.Op.Cell Biol. 12, 91-96.

Mullins, R. D., Heuser, J. A. & Pollard, T. D. (1998) The interaction of ARP2/3 complex with actin: nucleation, high affinity pointed end capping, formation of branching networks of filaments. Proc.Nat.Acad.Sci.USA. 95, 6181-6186.

Mullins, R. D., Kelleher, J. F., Xu, J. & Pollard, T. D. (1998) Arp2/3 complex from Acanthamoeba binds profilin and cross-links actin filaments. Mol.Cell Biol. 9, 841-852.

Mullins, R. D. & Pollard, T. D. (1999) Rho-family GTPases require the Arp2/3 complex to stimulate actin polymerization in Acanthamoeba extracts. Curr. Biol. 9, 405-415.

Mullins, R. D. & Pollard, T. D. (1999) Structure and function of the Arp2/3 complex. Curr.Op.Struct.Biol. 9, 244-249.

Mullins, R. D., Stafford, W. F. & Pollard, T. D. (1997) Structure, subunit topology, and actin-binding activity of the Arp2/3 complex from Acanthamoeba. J.Cell Biol. 136, 331-343.

Pantaloni, D., Boujemaa, R., Didry, D., Gounon, P. & Carlier, M. F. (2000) The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins.  Nature Cell Biol. 2, 385-391.

Pantaloni, D., Le Clainche, C. & Carlier, M. F. (2001) Mechanisim of actin-based motility. Science. 292, 1502-1506.

Pollard, T. D., Blanchoin, L. & Mullins, R. D. (2001) Actin dynamics. J. Cell Sci. 114, 3.

Ressad, F., Didry, D., Egile, C., Pantaloni, D. & Carlier, M.-F. (1999) Control of actin filament length and turnover by actin depolymerizing factor (ADF/Cofilin) in the presence of capping proteins and ARP2/3 complex.  J.Biol.Chem. 274, 20970-20976.

Robinson, R. C., Turbedsky, K., Kaiser, D. A., Marchand, J.-B., Higgs, H. N., Choe, S. & Pollard, T. D. (2001) Crystal structure of Arp2/3 complex.  Science. 294, 1679-1684.

Rohatgi, R., Nollau, P., Ho, H.-Y. H., Kirschner, M. W. & Mayer, B. J. (2001) Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. J. Biol.Chem. 276, 26448-26452.

Rozelle, A. L., Machesky, L. M., Yamamoto, M., Driessens, M. H. E., Insall, R. H., Roth, M. G., Luby-Phelps, K., Marriott, G., Hall, A. & Yin, H. L. (2000) Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Current Biology. 10, 311-320.

Schaerer-Brodbeck, C. & Riezman, H. (2000) Functional interactions between the p35 subunit of the Arp2/3 complex and calmodulin in yeast.M ol.Biol.Cell. 11, 1113-1127.

Suetsugu, S., Miki, H. & Takenawa, T. (2001) Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin prolymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J.Biol.Chem. 276, 33175-33180.

Suetsugu, S., Miki, H., Yamaguchi, H., Obinata, T. & Takenawa, T. (2001) Enhancement of branching efficiency by the actin filament-binding activity of N-WASP/WAVE2. J.Cell Sci. 114, 4533-4542.

Svitkina, T. M. & Borisy, G. G. (1999) Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia. J.Cell Biol. 145, 1009-1026.

Svitkina, T. M. & Borisy, G. G. (1999) Progress in protrusion:the tell-tale scar.  TIBS. 24, 432-436.

Volkmann, N., Amann, K. J., Stoilova-MvPhie, S., Egile, C., Winter, D. C., Hazelwood, L., Heuser, J. E., Li, R., Pollard, T. D. & Hanein, D. (2001) Structure of Arp2/3 complex in its activated state and in actin filament branch junction.  Science. 293, 2456-2459.

Weaver, A. M., Karginov, A. V., Kinley, A. W., Weed, S. A., Li, Y., Parsons, J. T. & Cooper, J. A. (2001) Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Current Biology. 1, 370-374.

Weed, S. A., Karginov, A. V., Schafer, D. A., Weaver, A. M., Kinley, A. W., Cooper, J. A. & Parsons, J. T. (2000) Cortactin localization to sites of actin assembly in lamellipodia requires interaction with F-actin and the Arp2/3 complex.  J.Cell Biol. 151, 29-40.

Weeds, A. & Yeoh, S. (2001) Action at the Y-branch.  Science. 294, 1660-1661.

Welch, M. D. (1999) The world according to ARP: regulation of actin nucleation by the Arp2/3 complex.  Trends Cell Biol. 9, 423-427.

Welch, M. D., DePace, A. H., Verma, S., Iwamatsu, A. & Mitchison, T. J. (1997) The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.  J.Cell Biol. 138, 375-384.

Welch, M. D., Iwamatsu, A. & Mitchison, T. J. (1997) Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. Nature. 385, 265-269.

Welch, M. D., Rosenblatt, J., Skoble, J., Portnoy, D. A. & Mitchison, T. J. (1998) Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science. 281, 105-108.

Winter, D., Lecher, T. & Li, R. (1999) Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family member. Curr.Biol. 9, 501-504.

Yamaguchi, H., Miki, H., Suetsugu, S., Ma, L., Kirschner, M. W. & Takenawa, T. (2000) Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP. PNAS. 97, 12631-12636.

Yarar, D., To, W., Abo, A. & Welch, M. D. (1999) The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex.  Curr.Biol. 9, 555-558.

Zalevsky, J., Grigorova, I. & Mullins, R. D. (2001) Activation of the Arp2/3 complex by the Listeria ActA protein. J.Biol.Chem. 276, 3468-3475.

Zalevsky, J., Lempert, L., Kranitz, H. & Mullins, R. D. (2001) Different WASP family proteins stimulate different Arp2/3 complex-dependent actin nucleating activities  Curr. Biol. 11, 1903-1913.

Zigmond, S. H. (1998) Actin cytoskeleton: The Arp2/3 complex gets to the point. Current Biol. 8, 654-657.

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