obvious connection between cytokinesis and disease is cancer where the
uncontrolled division and growth of cells produces pathology. In
this situation cytokinesis is merely the result of the general
loss of cellular regulation and control. However in a few cases
failures of cytokinesis lead to genetic instability by incorrect
division of the chromosomes. In oral squamous carcinoma cells
spindle poles are often malformed leading to further chromosomal
et al, 2000),
and in other cells types muti-nuclearity results from an increase in
aurora kinase expression which leads to common failures of cytokinesis (Tatsuka
et al, 1998).
Asbestos dust physically disrupts cytokinesis by the fibres becoming
trapped within the cleavage furrow (Jensen
& Watson, 1999),
leading to chromosome loss aneuploidy and general genetic instability.
Jensen, C.G. & Watson, M. (1999). Inhibition of
cytokinesis by asbestos and synthetic fibres. Cell Biol. Int. 23(12),
Meraldi, P., Honda, R. & Nigg, E.
A. (2002) Aurora-A overexpression reveals tetraploidization as a major
route to centrosome amplification in p53-/- cells., EMBO J. 21,
S., Shuster, M., Huang, X., Gharaibeh, B., Enyenihi, A. H., Petersen, I.
& Gollin, S. M. (2000) Chromosomal instability and cytoskeletal
defects in oral cancer cells. PNAS. 97, 303-308.
Tatsuka, M., Katayama, H., Ota, T., Tanaka, T.,
Odashima, S., Suzuki, F., & Terada, Y. (1998) Multinuclearity and increased
ploidy caused by overexpression of the aurora- and IpI1-like midbody-associated
protein mitotic kinase in human cancer cells. Cancer Res. 58, 4811-4816.