(top) was the first member of the group to be sequenced (Kwiatkowski).
Its six domains are a repeat of two sets of three in that G1 (dark blue)
is most like G4 (light blue), G2 like G5, and G3, like G6 (Way
The villin group are characterised by the possesion of the villin head
piece (Purple oblong) at the C-terminus. One of the most divergent forms
is EhABPH from Entamoeba histolytica (Ebert
et al, 2000)
which has a coronon-like N-terminal region followed by gelsolin/villin
domain but lacking G1.
information look under each particular ABP in the Encyclopaedia of
Ebert, F., Guillen, N., Leippe, M.
& Tannich, E. (2000) Molecular cloning and cellular localization of
an unusual bipartite Entamoeba histolytica polypeptide with
similarity to actin binding proteins., Mol.Biochem.Parasitol. 111,
Kwiatkowski, D. J., Stossel, T. P.,
Orkin, S. H., Mole, J. E., Colten, H. R. & Yin, H. L. (1986) Plasma
and cytoplasmic gelsolins are encoded by a single gene and contain a
duplicated actin-binding domain, Nature. 323, 455-458.
Way, M. & Weeds, A. G. (1988)
Nucleotide sequence of pig plasma gelsolin. Comparison of protein
sequence with human gelsolin and other actin-severing proteins shows
strong homologies and evidence for large internal repeats, J. Mol.
Biol. 203, 1127-1133.