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The PX Domain

A phosphoinositide-binding domain present in a large number of proteins, named after phox a PI-binding protein in which the function was first identified (Xu et al, 2001). In addition to binding PI-lipds, some PX domains also contain a PxxP motif which can be a target for SH3 domain binding, it has been shown that such a motif within the PX region of p47phox binds its own C-terminus through a SH3 interaction (Hiroaki et al, 2001).



Ellson, C. D., Andrews, S., Stephens, L. R. & Hawkins, P. T. (2002) The PX domain: a new phosphinositide-binding module. J.Cell Sci. 115, 1099-1105.

Hiroaki, H., Ago, T., Ito, T., Sumimoto, H. and Kohda, D. (2001). Solution structure of the PX domain, a target of the SH3 domain. Nat.Struct.Biol. 8, 526-530.

Xu, Y., Seet, L.-F., Hanson, B. & Hong, W. (2001) The Phox homology (PX) domain, a new player in phosphoinositide signalling. Biochem. J. 360, 513-530.

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