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PAK (p21-activated Kinase)

At least one isoform of PAK is known to bind actin directly (Cau et al, 2001).  PAKs are kinases that are activated by the GTPases Rac and Cdc42. Once bound to activated GTPases, the complex becomes autophosphorylate and goes on to phosphorylate other substrates such as LIMKinase.  LIMKinase then phosphorylates ADF/cofilin.

Cau, J., Faure, S., Comps, M., Delsert, C. & Morin, N. (2001) A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization., J. Cell Biol.

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