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Palladin

An Ig containing actin-binding protein that also binds ezrin (Mykkanen et al, 2001). Palladin is localized in cells to stress fibers and cell adhesion (Parast & Otey, 2000). Palladin is homologous to myotilin, a structural protein of the striated muscle Z-disc, but palladin is present in smooth muscle and non-muscle tissues, where is co-localises to stress  fibres and cell adhesion plaques (Parast & Otley, 2000).

References:-

Mykkanen, O.-M., Gronholm, M., Ronty, M., Lalowski, M., Salmikangas, P., Suila, H. & Carpen, O. (2001) Characterization of human palladin, a microfilament-associated protein., Mol.Biol.Cell. 12, 3060-3073.

Parast, M. M. & Otey, C. A. (2000) Characterization of palladin, a novel protein localized to stress fibers and cell adhesions., J. Cell Biol. 150, 643-655.

Bang, M. L., Mudry, R. E., McElhinny, A. S., Trombitas, K., Geach, A. J., Yamasaki, R., Sorimachi, H., Granzier, H., Gregorio, C. C. & Labeit, S. (2001) Myopalladin, a novel 145-kilodalton sarcomeric protein with mutliple roles in Z-disc and I-band assemblies., J.Cell Biol. 153, 413-427.

 
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