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Plectin

Page updated 13/11/03

A giant protein (c500 kDa) which binds actin, microtubules and intermediate filaments.  It binds actin through a CH domain close to the N-terminus.  Plectin is localised to the hemidesmosome, where is cross-links the intermediate filament system to the hemidesmosome itself.

 

References:-

Allen, P. G. & Shah, J. V. (1999) Brain and brawn: plectin as regulator and reinforcer of the cytoskeleton. BioEssays. 21, 451-454.

Andra, K., Nikolic, B., Stocher, M., Drenckhahn, D. & Wiche, G. (1998) Not just a scaffolding: plectin regulates actin dynamics in cultured cells. Genes & Development. 12, 3442-3451.

Foisner, R. & Wiche, G. (1987) Structure and hydrodynamic properties of plectin molecules., J.Mol.Biol. 198, 515-531.

Geerts, D., Fontao, L., Nievers, M. J., Schaapveld, R. Q. J., Purkis, P. E., Wheeler, G. N., Lane, E. B., Leig, I. M. & Sonnenberg, A. (1999) Binding of integrin a6b4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding. J.Cell Biol. 147, 417-434.

Litjens SHM, Koster J, Kuikman I, van Wilpe S, de Pereda JM, Sonnenberg A. 2003. Specificity of binding of the plectin actin-binding domain to b4 integrin. Mol Biol Cell 14, 4039-4050.

Rezniczek, G. A., de Pereda, J. M., Reipert, S. & Wiche, G. (1998) Linking integrin a6b4-based cell adhesion to the intermediate filament cytoskeleton: Direct interaction between the b4 subunit and plectin at multiple molecular sites. J. Cell Biol. 141, 209-225.

 Wiche, G., Becker, B., Luber, K., Weitzer, G., Castaņon, M. J., Hauptmann, R., Stratowa, C. & Stewart, M. (1991) Cloning and sequencing of rat plectin indicates a 466-kD polypeptide chain with a three-domain structure based on a central alpha-helical coiled-coil. J.Cell Biol. 114, 83-99.

 
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