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The p53 protein is a tumour suppressor gene whose loss by mutation or deletion is associated with cancer.  p53 is normally involved in cell-cycle control and apoptosis.  The protein has been reported to bind microtubules (Giannakakou et al, 2000) and F-actin (Metcalfe et al, 1999; Okorokov et al, 2002).  The influence that p53 has over the cytoskeleton means that it regulates cell locomotion (Yao et al, 2003).



Giannakakou, P., Sackett, D. L., Ward, Y., Webster, K. R., Blagosklonny, M. V. & Fojo, T. (2000) p53 is associated with cellular microtubules and is transported to the nucleus by dynein., Nature Cell Biol. 2, 709-717.

Metcalfe, S., Weeds, A., Okorokov, A. L., Milner, J., Cockman, M. & Pope, B. (1999) Wild-type p53 protein shows calcium-dependent binding to F-actin.  Oncogene. 18, 2351-2355.

Okorokov, A. L., Rubbi, C. P., Metcalfe, S. & Milner, J. (2002) The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage. Oncogene. 21, 356-367.

Yao, W., Gu, L., Sun, D., Ka, W., Wen, Z. & Chien, S. (2003) Wild type p53 gene causes reorganization of cytoskeleton and , therefore, the impaired deformability and difficult migration of murine erythroleukemia cells. Cell Motil Cytoskeleton. 56, 1-12.

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