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Actin-Regulating Kinases

Two members Ark1p and Prk1p first recognised in the budding yeast Saccharomyces cerevisiae (Cope et al, 1999) to regulate the actin cytoskeleton by direct association. Both Ark1p and Prk1p are localized to the cortical actin patches and Prk1p is known to phosphorylate Ent1p - the yeast epsin (an actin bundling protein) homolog (Watson et al, 2001). Prk1p and epsin are implicated in a role in endocytosis (Watson et al, 2001).


Cope, M. J., Yang, S., Shang, C. & Drubin, D. G. (1999) Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast., J. Cell Biol. 144, 1203-1218.

Watson, H. A., Cope, M. J. T. V., Groen, A. C., Drubin, D. G. & Wendland, B. (2001) In vivo role for actin-regulating kinases in endocytosis and yeast epsin phosphorylation., Mol.Biol.Cell. 12, 3668-3679.

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