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Arginine Kinase

Arginine kinase (AK) belong to a class of kinases that play a role in the maintenance of ATP levels by the phosphorylation of the so called "phosphagens"  which then serve as a high energy source from which ATP can be rapidly replenished. In a wide variety of invertebrates phosphoarginine is the most important phosphagen, whereas in vertebrates this is phosphocreatine.  (Athletes take creatine orally to increase their energy storage capacity).  Some AKs contain an a-actinin like actin binding region (Pereira et al, 2000), and it has been shown that AK from mollusc muscle (Scallop, Pecten maximus) binds actin with reasonable affinity (Kd = c 4mm) (Reddy et al, 1992).



Pereira, C. A., Alonso, G. D., Paveto, M. C., Iribarren, A., Cabanas, M. L., Torres, H. N. & Flawia, M. M. (2000) Trypanosoma cruzi arginine kinase characterization and cloning., J. Biol.Chem. 275, 1495-1501.

Reddy, S. R. R., Houmeida, A., Benyamin, Y. & Roustan, C. (1992) Interaction in vitro of scallop muscle arginine kinase with filamentous actin., Eur. J. Biochem. 206, 251-257.

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