kinase (AK) belong to a class of kinases that play a role in the maintenance of
ATP levels by the phosphorylation of the so called "phosphagens"
which then serve as a high energy source from which ATP can be rapidly
replenished. In a wide variety of invertebrates phosphoarginine is the most
important phosphagen, whereas in vertebrates this is phosphocreatine. (Athletes
take creatine orally to increase their energy storage capacity). Some AKs
contain an a-actinin
like actin binding region (Pereira
et al, 2000),
and it has been shown that AK from mollusc muscle (Scallop, Pecten maximus)
binds actin with reasonable affinity (Kd = c 4mm)
(Reddy et al,
Pereira, C. A., Alonso,
G. D., Paveto, M. C., Iribarren, A., Cabanas, M. L., Torres, H. N. & Flawia,
M. M. (2000) Trypanosoma cruzi arginine kinase characterization and
cloning., J. Biol.Chem. 275, 1495-1501.
Reddy, S. R. R.,
Houmeida, A., Benyamin, Y. & Roustan, C. (1992) Interaction in vitro
of scallop muscle arginine kinase with filamentous actin., Eur. J. Biochem.