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b-CAP73

Page updated 13th Nov '03

An actin binding protein that binds only the b-isoform of actin (Shuster et al, 1996).  The cDNA encodes a protein with an expected molecular weight of some 150kDa, but the protein was originally isolated as a 73kDa protein (hence the name) (Welch & Herman, 2002). b-CAP73 has six predicted ankyrin-like repeats at the N-terminus.

 

References:-

Riley, K. N., Maldonado, A. E., Tellier, P., D'Souza-Schorey, C. & Herman, I. M. (2003) bcap73-ARF6 interactions modulate cell shape and motility after injury in vitro. Mol Biol Cell. 14, 4155-4161.

Shuster, C.B., Lin, A.Y., Nayak, R., & Herman, I.M. (1996). b-CAP73: A novel b actin-specific binding protein. Cell Motil.Cytoskeleton 35, 175-187.

Welch, A. Y. & Herman, I. M. (2002) Cloning and characterization of bCAP73, a novel regulator of b-actin assembly. Int. J. Biochem.Cell Biol. 1233.

 
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