116 Kda protein from Dictyostelium discoideum that was found to be
homologous to Acan 125, a previously identified binding partner of Myosin I from
Acanthamoeba castellanii (Xu
et al, 1995). CARMIL binds a number of partners including the
Arp2/3 complex, capZ protein, and Myosin I. The sequence contains a
verprolin (WISP) like G-actin binding like motif (GRDALLGDIRKGMKLKKAETNDRSAPIV),
although actual actin binding has yet to be demonstrated.
Jung, G., Remmert, K., Wu, X., Volosky, J. M.
& Hammer III, J. A. (2001) The Dictyostelium CARMIL protein links
capping protein and the Arp2/3 complex to type I myosins through their SH3
domains., J. Cell Biol. 153, 1475-1497.
Xu, P., Zot, A. S. & Zot, H. G. (1995)
Identification of Acan125 as a myosin-I-binding protein present with myosin-I on
cellular membranes, J.Biol.Chem. 270, 25316-25319.