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Acan125 (CARMIL)

A 116 Kda protein from Dictyostelium discoideum that was found to be homologous to Acan 125, a previously identified binding partner of Myosin I from Acanthamoeba castellanii (Xu et al, 1995). CARMIL binds a number of partners including the Arp2/3 complex, capZ protein, and Myosin I.  The sequence contains a verprolin (WISP) like G-actin binding like motif (GRDALLGDIRKGMKLKKAETNDRSAPIV), although actual actin binding has yet to be demonstrated.


Jung, G., Remmert, K., Wu, X., Volosky, J. M. & Hammer III, J. A. (2001) The Dictyostelium CARMIL protein links capping protein and the Arp2/3 complex to type I myosins through their SH3 domains., J. Cell Biol. 153, 1475-1497.

Xu, P., Zot, A. S. & Zot, H. G. (1995) Identification of Acan125 as a myosin-I-binding protein present with myosin-I on cellular membranes, J.Biol.Chem. 270, 25316-25319.

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