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Cingulin

A component of the epithelial tight junction (Citi et al, 1988; 1989) that binds ZO-1, ZO-2, ZO-3, myosin II (Cordenonsi et al, 1999), and actin (D'Arti & Citi, 2001).  Cingulin is thought to form a parallel dimer with globular head and tail region separated by a rod-like central region (Cordenonsi et al, 1999).  Cingulin is thought to cross-link actin into a sedimentable complex with actin possibly through a region within residues 101-296 in the dimer.  No similarity between known actin-binding domains in other ABPs and this region of cingulin was detected (D'Arti & Citi, 2001).

References:-

Citi, S., Sabanay, H., Kendrick-Jones, J. & Geiger, B. (1989) Cingulin: characterization and localization, J.Cell Sci. 93, 107-122.

Citi, S., Sabanay, H., Jakes, R., Geiger, B. & Kendrick-Jones, J. (1988) Cingulin, a new peripheral component of tight junctions, Nature. 333, 272-276.

Cordenonsi, M., D'Arti, F., Hammar, E., Parry, D. A., Kendrick-Jones, J., Shore, D. & Citi, S. (1999) J.Cell Biol. 147, 1569-1582.

D'Arti, F. & Citi, S. (2001) Cingulin interacts with F-actin in vitro., FEBS letters. 507, 21-24.

 
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