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Diaphanous

Page updated 30/5/02

A formin-homology (FH) protein, first identified in Drosophila (Castrillon & Wasserman, 1994), and subsequently in mammals (Watanabe et al, 1997). Diaphanous (or mDia1), coordinates both the actin and the microtubule systems in an incompletely understood mechanism involving Rac, Rho and their various effectors (Tsuji et al, 2002).

References:-

Alberts, A. S. (2001) Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulated domain., J.Biol.Chem. 276, 2824-2830.

Castrillon, D. H. & Wasserman, S. A. (1994) Development. 120, 3367-3377.

Ishizaki, T., Morishima, Y., Okamoto, M., Furuyashiki, T., Kato, T. & Narumiya, S. (2001) Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1., Nature Cell Biol. 3, 8-14.

Tsuji, T., Ishizaki, T., Okamoto, M., Higashida, C., Kimura, K., Furuyashiki, T., Arakawa, Y., Birge, R. B., Nakamoto, T., Hirai, H. & Narumiya, S. (2002) ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts. J.Cell Biol. 157, 819-830.

Watanabe, N. , Maduale, P., Reid, T., Ishizaki, T., (1997). "p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin." EMBO.J. 16, 3044-3056.

Watanabe, N., Kato, A., Ishizaki, T. & Narumiya, S. (1999) Cooperation between mDia1 and ROCK in Rho-induced actin organization., Nature Cell Biol. 1, 136-143.

 
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