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Dolastatins

Page updated 3/10/02

Extracted from the sea hare Dolabella auricularia, the dolastatins are a group of actin-binding drugs that competes with phalloidin for binding (Bai et al, 2002).  The drug like (-)-doliculide isolated from the same sea hare dolastatins are suspected of actually accumulating in the sea hare from cyanobacteria it is feeding on.  The structure of dolastatins are similar to phalloidin.
Reference:-

Bai, R., Covell, D. G., Liu, C., Ghosh, A. K. & Hamel, E. (2002) (-)-Doliculide, a new macrocyclic depsipeptide enhancer of actin assembly. J. Biol. Chem. 277, 32165-32171.

 
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