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Dystroglycan

Page updated 16/10/03

Dytsroglycan are transmembranous proteins that connect the extracellular matrix with the cytoskeleton via dystrophin and utrophin.  Recently (Chen et al, 2003) it has been reported that b-dystroglycan binds directly to actin, aswell as indirectly through dystrophin.  There maybe two actin-binding sites in b-dystroglycan as the protein causes actin bundle formation in vitro at least.  There are regions within the protein that are  homologous to other actin binding proteins (Utrophin, Gelsolin, VASP and tropomodulin).

 

 Figure 1. The dystroglycan complex. 
References

Chen, Y.-J., Spence, H. J., Cameron, J. M., Jess, T., Ilsley, J. L. & Winder, S. J. (2003) Direct interaction of b-dystroglycan with F-actin. Biochem.J. 375, 329337.

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