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EAST

EAST is an EGF receptor substrate that binds actin (as does the EGF receptor its self - see below).  The name comes from EGFR-Associated protein with SH3 and TAM domains, and is not to be confused with another protein called EAST that is a nucleoskeletal protein (part of the nuclear matrix) (see Lasky, 2000). As the name implies EAST binds the EGF receptor directly (Lohi et al, 1998).  The N-terminus of EAST is responsible for binding actin (Lohi & Lehto, 1998).  EAST also binds Eps15 another ABP (see below). EAST is enriched at focal adhesions and in some cells (MDCK) at cell-cell contacts (Lohi & Lehto, 1998).

References:-

Lasky, L.A. (2000) The nucleoskeleton: go EAST, young man. Nature Cell Biology, 2, E74-E75.

Lohi, O., Poussu, A., Merilainen, J., Kellokumpu, S., Wasenius, V.-M. and Lehto, V.-P. (1998) "" J.Biol.Chem. 273, 14806-14816.

Lohi, O. & Lehto, V.-P. (1998) "EAST, a novel EGF receptor substrate, associates with focal adhesions and actin filaments." FEBS letters. 436, 419-423.

 
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