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Fimbrin (plastin)

 

A 67kd monomeric actin filament bundling protein which has two ABP-120 like actin binding motifs (two pairs of CH domains) but has no rod-like domain. Fimbrin has two EF hands (domains which typically bind calcium) but as no calcium sensitivity has been demonstrated, this is of uncertain significance. Fimbrin can be phosphorylated on serine in vivo.

References:-

Adam, T., Arpin, M., Prevost, M.-C., Gounon, P. & Sansonetti, P. J. (1995) Cytoskeletal rearrangements and the function role of T-plastin during entry of Shigella flexneri into HeLa cells., J. Cell Biol. 129, 367-381.

Babb, S. G., Matsudaira, P., Sato, M., Correia, I. & Lim, S.-S. (1997) Fimbrin in podosomes of monocyte-derived osteoclasts, Cell Mot.Cytoskel. 37, 308-325.

Bartles, J. R. (2000) Parallel actin bundles and their multiple actin-bundling proteins., Curr.Op.Cell Biol. 12, 72-78.

Cheng, D., Marner, J. & Rubenstein, P. A. (1999) Interaction in vivo and in vitro between the yeast fimbrin, SAC6P, and a polmerization-defective yeast actin (V266G and L267G)., J.Biol.Chem. 274, 35873-35880.

deArruda, M. V., Watson, S., Lin, C.-S., Levitt, J. & Matsudaira, P. (1990) Fimbrin is a homologue of the cytoplasmic phosphoprotein plastin and has domains homologous with calmodulin and actin gelation proteins, J. Cell Biol. 111, 1069-1079.

Ezzell, R. M., Chafel, M. M. & Matsudaira, P. T. (1989) Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium., Development. 106, 407-419.

Ezzell, R. M., Leung, J., Collins, K., Chafel, M. M., Cardozo, T. J. & Matsudaira, P. T. (1992) Expression and Localization of Villin, Fimbrin, and Myosin I in Differentiating Mouse F9 Teratocarcinoma Cells., Developmental Biol. 151, 575-585.

Fukui, Y., de Hostos, E., Yumura, S., Kitanishi-Yumura, T. & Inoué, S. (1999) Architectural dynamics of F-actin in eupodia suggests their role in invasive locomotion in Dictyostelium., Exp.Cell Res. 249, 33-45.

Hanein, D., Matsudaira, P. & DeRosier, D. J. (1997) Evidence for a conformational change in actin induced by fimbrin (N375) binding., J.Cell Biol. 139, 387-396.

Hisano, T., Ono, M., Nakayama, M., Naito, S., Kuwano, M. & Wada, M. (1996) Increased expression of T-plastin gene in cisplatin-resistant human cancer cells: identification by mRNA differential display., FEBS letters. 397, 101-107.

Honts, J. E., Sandrock, T. S., Brower, S. M., O'Dell, J. L. & Adams, A. E. M. (1994) Actin mutations that show suppression with fimbrin mutations identify a likely fimbrin-binding site on actin, J. Cell Biol. 126, 413-422.

Jones, S. L. & Brown, E. J. (1996) FcgRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils., J.Biol.Chem. 271, 14623-14630.

Jones, S. L., Wang, J., Turck, C. W. & Brown, E. J. (1998) A role for actin-bundling protein L-plastin in the regulation of leukocyte integrin function., Proc.Nat.Acad.Sci. USA. 95, 9331-9336.

Karpova, T. S., Tatchell, K. & Cooper, J. A. (1995) Actin filaments in yeast are unstable in the absence of capping protein or fimbrin, J. Cell Biol. 131, 1483-1493.

Kocks, C. & Cossart, P. (1993) Directional actin assembly by listeria-monocytogenes at the site of polar surface expression of the acta gene-product invllving the actin-bundling protein plastin (fimbrin), Infectious Agents And Disease Reviews Issues And Commentary. 2, 207-209.

Kovar, D. R., Gibbon, B. C., McCurdy, D. W. & Staiger, C. J. (2001) Fluorescently-labeled fimbrin decorates a dynamic actin filament network in living plant cells., Planta. 213, 390-395.

Lollike, K., Johnsen, A. H., Durussel, I., Borregaard, N. & Cox, J. A. (2001) Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner., J. Biol.Chem. 276, 17762-17769.

Matsudaira, P. (1994) The fimbrin and alpha-actinin footprint on actin, J. Cell Biol. 126, 285-287.

Nakano, K., Satoh, K., Morimatsu, A., Ohnuma, M. & Mabuchi, I. (2001) Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton., Mol.Biol.Cell. 12, 3515-3526.

Prévost, M. C., Lesourd, M., Arpin, M., Vernel, F., Mounier, J., Hellio, R. & Sansonetti, P. J. (1992) Unipolar reorganization of F-actin layer at bacterial division and bundling of actin filaments by plastin correlate with movement of Shigella flexneri within HeLa cells., Infection and Immunity. 60, 4088-4099.

Rosales, C., Jones, S. L., McCourt, D. & Brown, E. J. (1994) Bromophenacyl bromide binding to the actin-bundling protein 1-plastin inhibits inositol trisphosphate-independent increase in Ca2+ in human neutrophils, Cell Biology. 91, 3534-3538.

Volkmann, N., DeRosier, D. J., Matsudaira, P. & Hanein, D. (2001) An atomic modelof actin filaments cross-linked by fimbrin and its implications for bundle assembly and function., J.Cell Biol. 153, 947-956.

Wang, J. & Brown, E. J. (1999) Immune complex-induced intgrin activation and L-plastin phosphorylation require protein kinase A., J.Biol.Chem. 274, 24349-24356.

Wang, J., Chen, H. & Brown, E. J. (2001) L-plastin peptide activation of avb3-mediated adhesion requires integrin conformational change and actin filament disassembly., J.Biol.Chem. 276, 14474-14481.

Watanabe, A., Yonemura, I., Gonda, K. & Numata, O. (2000) Cloning and sequencing of the gene for a Tetrahymena fimbrin-like protein., J.Biochem. 127, 85-94.

Wu, J.-Q., Bahler, J. & Pringle, J. R. (2001) Roles of a fimbrin and an a-actinin-like protein in fission yeast cell polarization and cytokinesis., Mol.Biol.Cell. 12, 1061-1077.

Zhou, D., Mooseker, M. S. & Galán, J. E. (1999) An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin., PNAS. 96, 10176-10181.

 
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