EDInfo Biomedical Sciences Maciver Lab. Home ABP  A-Z Encyclopaedia Amoebae Protist Links Cytoskeleton Links Site Index


Many enzymes of the glycolytic pathway have been found to bind the actin cytoskeleton (see Aldolase, Phosphofructokinase) (Knull et al, 1992). Several observations make it likely that glucokinase is amongst them.  The enzyme co-localizes with actin (Murata et al, 1997),  glucokinase is released from permeabilized cells upon treatment with cytochalasin and phalloidin (Agius & Peak, 1993), and the yeast homolog has been reported to bind actin by the yeast-two hybrid method (Amberg et al, 1995).


Agius, L. & Peak, M. (1993). "" Biochem. J. 296, 785-796.

Amberg, D. C., Basart, E.,  & Botstein D. (1995). “Defining protein interactions with yeast actin in vivo.” Nature Struct. Biol. 2(1): 28-35.

Murata, T., Katagiri, H., Ishihara, H., Shibasaki, Y., Asano, T., Toyoda, Y., Pekiner, B., Pekiner, C., Miwa, I. & Oka, Y. (1997). "Co-localization of glucokinase with actin filaments. FEBS letters, 406, 109-113.

  EDInfo Biomedical Sciences Cytoskeletal Links Encyclopaedia of A.B.P.s The Amoebae Protozoology links Glossary of Amoeba terms   Maciver Lab Home