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Histidine rich protein II

Page updated 20/5/03

A pH sensitive actin and phosphatidylinositol 4,5-bisphosphate binding protein from Plasmodium falciparum (Benedetti et al, 2003). Hrp II binds F-actin at pH 6.0 but not at pH 7.5, in a manner reminiscent of ADF/Cofilin as at pH 7.5 Hrp II binds G-actin and prevents its sedimentation. Hrp II is like hisactophilin and has 28% homology but this is due to the fact that both proteins contain so much histidine. 

Benedetti, C. E., Kobarg, J., Pertinhez, T. A., Gatti, R. M., de Souza, O. N., Spisni, A. & Meneghini, R. (2003) Plasmodium falciparum histidine-rich protein II binds to actin, phosphatidylinositol 4,5-bisphosphate and erythrocyte ghosts in a pH-dependent manner undergoes coil-tphelix transitions in anionic micelles., Mol. Biochem.Parasitol. 128, 157-166.

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