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Hrp36

Page updated 20/5/03

An RNA-binding protein that binds actin (Percipalle et al, 2001), and the Balbiani Ring (BR) particle, in both the nucleus and the cytoplasm.  Hrp36 is added cotranscriptionally with BR-specific mRNA and transported into the cytosol via the nuclear pore.  As actin contains two leptomyxin sensitive nuclear export signals (Wada et al, 1998), it is possible that the BR particle is directed out of the nucleus via these sites on actin.
Nuclear Actin Nuclear Actin-Binding proteins Nuclear Matrix
References:-

Percipalle, P., Zhao, J., Pope, B., Weeds, A., Lindberg, U. & Daneholt, B. (2001) Actin bound to the heterogeneous nuclear ribonucleoprotein hrp36 is associated with Balbiani ring mRNA from the gene to polysomes. J.Cell Biol. 153, 229-236.

Wada, A., Fukuda, M., Mishima, M. & Nishida, E. (1998) Nuclear export of actin; a novel mechanism regulating the subcellular localization of a major cytoskeletal protein. EMBO J. 17, 1635-1641.

 
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