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IP3 Kinase A

Inositol 1,4,5-trisphosphate 3-kinase A ( IP3 kinase A) is the enzyme that terminates the IP3 signal cascade by modifying it to IP4.  IP3 is produced from phosphatidyl inositol 4,5-bis phosphate (PIP2) by  activated  phospholipase C, IP3 then opens calcium gates usually on the ER or microsomes.  IP3kinaseA has been found to bind directly to F-actin via a proline rich N-terminus domain consisting of 66 amino-acids (Schell et al, 2001).  IP3kinaseA co localizes with F-actin in dendritic spines of cultured hippocampal neurons and in HeLa cells when it was artificially expressed as a GFP fusion protein.


Schell, M. J., Erneux, C. & Irvine, R. F. (2001) Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus., J.Biol.Chem. 276, 37537-37546.

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