(5LO) (Provost et
al, 2001) an
enzyme pivotally involved in the production of leukotrienes from arachidonic
acid. 5LO is itself an actin-binding protein (Lepley
& Fitzpatrick, 1994;
Provost et al,
17 kDa actin-binding protein coactosin,
isolated from Dictyostelium (de
Hostos et al, 1993)
since found in humans where it has been discovered to be a binding partner for 5LO.
human version of coactosin is named CLP (Coactosin-Like Protein). Another
lipoxygenase, 12/15-lipoxygenase (12/15LO) has been implicated in actin
polymerization in macrophages (Miller
et al, 2001),
this enzyme catalyses the peroxylation of double bonds of fatty acids.
de Hostas, E. L., B. Bradtke, et al.
(1993). “Coactosin, a 17 kDa F-actin binding protein from Dictyostelium
Mot.Cytoskeleton 26, 181-191.
Lepley, R.A. &
Fitzpatrick, F.A. (1994). J.Biol.Chem. 269, 24163-24168
Miller, Y. I., Cang, M.-K., Funk, C. D.,
Feramisco, J. R. & Witztum, J. L. (2001) 12/15-lipoxygenase translocation
enhances site-specific actin polymerization in marcophages phagocytosing
apoptotic cells., J.Biol.Chem. 276, 194310-19439.
Provost, P., Doucet, J., Hammarberg, T.,
Gerisch, G., Samuelsson, B. & Radmark, O. (2001) 5-Lipoxygenase interacts
with coactosin-like protein., J. Biol.Chem. 276, 16520-16527.