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LIM proteins

Page updated 26/6/03

The LIM-domain is contained within a wide range of proteins, some of which are also actin-binding proteins. The LIM-domain consensus consists of several cysteine and histidine which binds zinc ions and are responsible for protein:protein interactions. LimC and LimD from Dictyostelium (Khurana et al, 2002) bind actin directly and are localised to the leading edge.  FHL3 ( a LIM contining protein) has also been reported to bind actin (Coghill et al, 2003).

Coghill, I. D., Brown, S., Cottle, D. L., McGrath, M. J., Robinson, P. A., Nandurkar, H. H., Dyson, J. M. & Mitchell, C. A. (2003) FHL3 Is an Actin-binding Protein That Regulates {alpha}-Actinin-mediated Actin Bundling: FHL3 LOCALIZES TO ACTIN STRESS FIBERS AND ENHANCES CELL SPREADING AND STRESS FIBER DISASSEMBLY. J. Biol. Chem. 278, 24139-24152.

Khurana, T., Khurana, B. & Noegel, A. A. (2002) LIM proteins: association with the actin cytoskeleton. Protoplasma. 219, 1-12.

Khurana, B., Khurana, T., Khaire, N. & Noegel, A. A. (2002) Functions of LIM proteins in cell polarity and chemotactic motility. EMBO J. 21, 5331-5342.

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