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LIM proteins

Page updated 26/6/03

The LIM-domain is contained within a wide range of proteins, some of which are also actin-binding proteins. The LIM-domain consensus consists of several cysteine and histidine which binds zinc ions and are responsible for protein:protein interactions. LimC and LimD from Dictyostelium (Khurana et al, 2002) bind actin directly and are localised to the leading edge.  FHL3 ( a LIM contining protein) has also been reported to bind actin (Coghill et al, 2003).
References:-

Coghill, I. D., Brown, S., Cottle, D. L., McGrath, M. J., Robinson, P. A., Nandurkar, H. H., Dyson, J. M. & Mitchell, C. A. (2003) FHL3 Is an Actin-binding Protein That Regulates {alpha}-Actinin-mediated Actin Bundling: FHL3 LOCALIZES TO ACTIN STRESS FIBERS AND ENHANCES CELL SPREADING AND STRESS FIBER DISASSEMBLY. J. Biol. Chem. 278, 24139-24152.

Khurana, T., Khurana, B. & Noegel, A. A. (2002) LIM proteins: association with the actin cytoskeleton. Protoplasma. 219, 1-12.

Khurana, B., Khurana, T., Khaire, N. & Noegel, A. A. (2002) Functions of LIM proteins in cell polarity and chemotactic motility. EMBO J. 21, 5331-5342.

 
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