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MARKS related protein (MRP, MacMARKS, F52)

A 20kDa protein abundant in brain and testes (Aderem, 1992; Blackshear, 1993).  Unlike MARKS, MRP  neither bundles microfilaments nor alters the kinetics of actin polymerization (Wohnsland et al, 2000).  An interaction between MacMARKS and dynamitin (a subunit of the dynactin complex), has been detected in vitro (Yue et al, 2000) and in vivo (Jin et al, 2001)


Aderem, A. (1992). "The MARKS brothers: A family of protein kinase C substrates." Cell 71, 713-716.

Blackshear, P.J. (2000). "The MARKS family of cellular protein kinase C substrates." J.Biol.Chem. 268, 1501-1504.

Jin, T., Yue, L. & Li, J. (2001) In vivo interaction between dynamitin and MacMARKS detected by the fluorescence resonance energy transfer method., J.Biol.Chem. 276, 12879-12884.

Wohnsland, F.,  Steinmetz, M. O., Aebi, U. & Vergeres, G.  (2000). “MARCKS-related protein binds to actin without significantly affecting actin polymerization of network structure.” J.Struct.Biol. 131, 217-224.

Yue, L., Lu, S., Garces, J., Jin, T. & Li, J. (2000) Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanin-rich C kinase substrate interaction is involved in macrophage cell spreading., J.Biol.Chem. 276, 23948-23956.

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