EDInfo Biomedical Sciences Maciver Lab. Home ABP  A-Z Encyclopaedia Amoebae Protist Links Cytoskeleton Links Site Index


An actin and microtubule binding protein  (Gonzales et al, 1998).  The protein has been isolated on tubulin affinity columns and when purified then co-sedimented with F-actin.  Analysis of the binding to F-actin suggests an affinity (Ka) of 1x106M-1.  Immunofluorscence localises Mip-90 to both microtubules and actin in fibroblast with some nuclear staining also evident.  The leading edge where ruffling membrane underlain by a rich actin network was also stained with Mip-90 antibodies.


Gonzales, M., Cambiazo, V., & Maccioni, R.B. (1998). "The interaction of Mip-90 with microtubules and actin filaments in human fibroblasts. Exp.Cell Res. 239, 243-253.

  EDInfo Biomedical Sciences Cytoskeletal Links Encyclopaedia of A.B.P.s The Amoebae Protozoology links Glossary of Amoeba terms   Maciver Lab Home