actin bundling protein localised to the Z-disc of skeletal muscle (Weins
et al, 2001).
Myopodin is homologous to synaptopodin another actin-associated protein strongly
expressed in the kidney (Mundel
et al, 1997).
The actin-binding region in myopodin has been localised to a central region
between 410-563. This region contain no recognised actin-binding motif and
so may contain yet another actin-binding domain (see Actin-Binding
Motifs) (Weins et
Myopodin like a few other actin-binding proteins (e.g. ADF/Cofilin) accumulates
in the nucleus upon stress. However, unlike the situation with cofilin,
the nuclear actin "loops" seen in cells with increased myopodin did
stain with phalloidin.
Mundel, P., Heid, H.
W., Mundel, T. M., Kruger, M., Reiser, J. & Kriz, W. (1997) Synaptopodin: An
actin-associated protein in telencephalic dendrites and renal podocytes., JCB.
Weins, A., Schwarz, K., Faul, C., Barisoni,
L., Linke, W. A. & Mundel, P. (2001) Differentiation- and stress-dependent
nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.,
J.Cell Biol. 155, 393-403.