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Myopodin

An actin bundling protein localised to the Z-disc of skeletal muscle (Weins et al, 2001). Myopodin is homologous to synaptopodin another actin-associated protein strongly expressed in the kidney (Mundel et al, 1997).  The actin-binding region in myopodin has been localised to a central region between 410-563.  This region contain no recognised actin-binding motif and so may contain yet another actin-binding domain (see Actin-Binding Motifs) (Weins et al, 2001).  Myopodin like a few other actin-binding proteins (e.g. ADF/Cofilin) accumulates in the nucleus upon stress.  However, unlike the situation with cofilin, the nuclear actin "loops" seen in cells with increased myopodin did stain with phalloidin.

References:-

Mundel, P., Heid, H. W., Mundel, T. M., Kruger, M., Reiser, J. & Kriz, W. (1997) Synaptopodin: An actin-associated protein in telencephalic dendrites and renal podocytes., JCB. 139, 193-204.

Weins, A., Schwarz, K., Faul, C., Barisoni, L., Linke, W. A. & Mundel, P. (2001) Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein., J.Cell Biol. 155, 393-403.

 
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