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During embryogenesis in Drosophila (and other dipterans), "cellularization" occurs where each previously synchronously dividing nuclei within the syncitial embryo, becomes enveloped in its own membrane.  This process has been compared to cytokinesis (Sisson et al, 1999).  The process is driven by actin:myosin II interaction but other specialised ABPs have been implicated by association, amongst them gelsolin (Stella et al, 1994), anillin (Field et al, 1995), and nullo (Postner & Wieschaus, 1994).  Nullo was first identified through... Although not yet shown to interact with actin directly, it seems likely.


Field, C.M.& Alberts, B.M.(1995). "Anillin, a contractile ring protein that cycles from the nucleus to the cell cortex." J.Cell Biol. 131, 165-178.

Hunter, C., Sung, P., Schejter, E. D. & Wieschaus, E. (2002) Conserved domains of the Nullo protein required for cell-surface localization and formation of adherens junctions., Mol.Biol. Cell. 13, 146-157.

Postner, M.A. & Wieschaus, E.F. (1994). "The nullo protein is a component of the actin-myosin network that mediates cellularization in Drosophila melanogaster embryos." J.Cell Sci. 107, 1863-1873.

Rose, L.S. & Wieschaus, E. (1992). "The Drosophila cellularization gene nullo produces a blastoderm-specific transcript whose levels respomd to the nucleoplasmic ratio." Genes Dev. 6, 1255-1268.

Simpson, L. & Wieschaus, E. (1990). "Zygotic activity of the nullo locus is required to stabilize the actin-myosin network during cellularization in Drosophila embryos." Development 110, 851-863.

Sisson, J.C., Rothwell, W.F. & Sullivan, W. (1999). "Cytokinesis: Lessons from Rappaport and the Drosophila blastoderm embryo." Cell Biol Int. 23(12), 871-876.

Stella, M. C., H. Schauerte, et al. (1994). “Identification of secreted and cytosolic gelsolin in Drosophila.” J. Cell Biol. 125, 607-616.

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