bacteria Vibrio cholerae is a devastating human pathogen that killed
10,000 people/yr as recently as 1998! It is well known for producing
"cholera toxin" that ADP-ribosylates the inhibitory subunit of
adenylate cyclase leading to water loss, but the bacterium also produces a toxin
RTX that is now known to target actin (Fullner
& Mkananos, 2000).
The protein is huge and at 484 kDa, it is the largest toxin yet described.
K.J. & Mekananos, J.J. (2000). "In vivo covalent cross-linking
of cellular actin by the Vibrio cholerae RTX toxin." EMBO J. 19(20),