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Scinderin (adseverin)  

A pH and Ca2+ regulated member of the gelsolin super family of actin filament severing proteins that seems to function specifically to cleave actin filament to permit vesicles to dock during regulated secretion. 

Click here for a diagram of the domain structure of the Gelsolin/Villin family.

References:-

Castillo, A. R. D., S. Lemaire, et al. (1990). "Chromaffin cell scinderin, a novel calcium." EMBO Journal 9(1), 43-52.

Castillo, A. R. D., M. L. Vitale, et al. (1992). "Ca2+ and pH Determine the Interaction of Chromaffin Cell Scinderin with Phosphatidylserine and Phosphatidylinositol 4,5,-Biphosphate and Its Cellular Distribution During Nicotinic-receptor Stimulation and Protein Kinase C Activation." J.Cell Biol. 119(4), 797-810.

Marcu, M. G., L. Zhang, et al. (1996). "Recombinant scinderin, an F-actin severing protein, increases calcium-induced release of serotonin from permeabilized platelets, an effect blocked by 2 scinderin-derived actin-binding peptides and phosphatidylinositol 4,5-bisphosphate." Blood 87, 20-24.

Rodríguez Del Castillo, A., S. Lemaire, et al. (1990). "Chromaffin cell scinderin, a novel calcium-dependent actin filament severing protein." EMBO Journal 9(1), 43-52.

Rodríguez Del Castillo, R., M. L. Vitale, et al. (1992). "Ca2+ and pH determine the interaction of chromaffin cell scinderin with phosphatidylsering and phosphatidylinositol 4,5,-bisphosphate and its cellular distribution during nicotinic-receptor stimulation and protein kinase C activation." J. Cell Biol. 119, 797-810.

Sakurai, T., H. Kurokawa, et al. (1991). "The Ca2+ -dependent Actin Filament-severing Activity of 74-kDa Protein (Adseverin) Residues in Its NH2 -terminal Half." J.Biol.Chem. 266(7), 4581-4585.

Tchakarov, L., M.-L. Vitale, et al. (1990). "Expression of scinderin, an actin filament-severing protein, in different tissues." FEBS letters 268(1),  209-212.

Trifaró, J. M. (1993). "Scinderin and chromaffin cell actin network dynamics during exocytosis." J.Neurochem. 61, 187.

Trifaró, J. M., M. L. Vitale, et al. (1993). "Scinderin and chromaffin cell actin network dynamics during neurotransmitter release." J.Physiology-paris 87,  89-106.

Vitale, M. L., A. R. D. Castillo, et al. (1991). "Cortical Filamentous Actin Disassembly and Scinderin Redistribution during Chromaffin Cell Stimulation Precede Exocytosis, A Phenomenon Not Exhibited by Gelsolin." J.Cell Biol. 113(5), 1058-1067.

Zhang, L., M. G. Marcu, et al. (1996). "Recombinant scinderin enhances exocytosis, an effect blocked by 2 scinderin-derived actin-binding peptides and PIP2." Neuron 17, 287-296.

 
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