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A c210 kDa PDZ containing actin binding protein that is required for correct neural tube formation in the mouse.  The protein is expressed in two forms one containing, the other lacking the N terminal PDZ domain.  At the C-terminus of both forms is an EVH1 domain and a PDZ binding domain.  The protein is homologous in two regions with Apx a protein that is probably a sodium channel reulator, these regions are ASD1 and ASD2.

Soriano Lab Fred Hutch.Cancer Cent. Seattle


Hildebrand, J. D. & Soriano, P. (1999) Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice., Cell. 99, 485-497.

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