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An actin-binding protein from Salmonella enterica (Mitra et al, 2000).  SipA shows no obvious homology to any eukaryotic actin-binding protein but binds actin and also increases the bundling action of fimbrin (plastin) by an uncertain mechanism (Zhou et al, 1999a).  The protein binds actin directly through a C-terminal 226 amino-acid fragment that increases actin polymerization and decreases depolymerization (Zhou et al, 1999b).


McGhie, E. J., Hayward, R. D. & Koronakis, V. (2001) Cooperation between actin-binding proteins of invasive Salmonella: SipA potentiates SipC nucleation and bundling of actin., EMBO J. 20, 2131-2139.

Mitra, K.,  Zhou, D., & Galan, J.E.  (2000). “Biophysical characterization of SipA, an actin-binding protein from Salmonella enterica.” FEBS letters 482: 81-84.

Zhou, D., Mooseker, M. S. & Galán, J. E. (1999a) An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin., PNAS. 96, 10176-10181.

Zhou, D., Mooseker, M. S. & Galan, J. E. (1999b) Role of the Salmonella actin-binding protein SipA in bacterial internalization., Science. 283, 2092-2095.

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