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First identified by monoclonals made against gizzard (van der Loop et al, 1996).  Smoothelin is a minor component of smooth muscle (Wehrens et al, 1997). Two forms of smoothelin exist, smoothelin-A and smoothelin-B expressed in smooth muscle. The smoothelin gene (Smtn) in mice is on chromosome 11 band A2-A3 by fluorescence in situ hybridization (Rensen et al, 2000).  The actin binding region of the smoothelins are of the CH type found in spectrin a-actinins and dystrophins.


Rensen, S., Merkx, G., Doevendans, P., Geurts van Kessel, A. & van Eys G. (2000). "Structure and chromosome location of Smtn, the mouse smoothelin gene." Cytogenet Cell Genet 89, 225-229., 

van der Loop, F.T.L., Schaart, G., Timmer, E.D.J., Ramaekers, F.C.S., & Van Eys, G.J.J.M. (1996). J.Cell Biol. 134, 401-411.

Wehrens, X. H. T., Mies, B., Gimona, M., Ramaekers, F. C. S., Van Eys, G. J. J. M. & Small, J. V. (1997) Localization of smoothelin in avian smooth muscle and identification of a vascular-specific isoform, FEBS letters. 405, 315-320.

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