EDInfo Biomedical Sciences Maciver Lab. Home ABP  A-Z Encyclopaedia Amoebae Protist Links Cytoskeleton Links Site Index

Spire

First identified in Drosophila (Wellington et al, 1999) the Spire protein consists of four WH2 domains followed by a zinc finger (fig1). Actin is bound by the WH2 domains.  Recent evidence suggest that spire is involved in intracellular transport (Kerkhoff et al, 2001).

References:-

Kerkhoff, E., Simpson, J. C., Leberfinger, C. B., Otto, I. M., Doerks, T., Bork, P., Rapp, U. R., Raabe, T. & Pepperkok, R. (2001) The Spir actin organizers are involved in vesicle transport processes., Curr. Biol. 11, 1963-1968.

Otto, I. M., Raabe, T., Rennefahrt, U. E., Bork, P., Rapp, U. R. & Kerkhoff, E. (2000) The p150-Spir protein provides a link between c-jun N-terminal kinase function and actin organization., Curr. Biol. 10, 345-348.

Wellington, A., Emmons, S., James, B., Calley, J., Grover, M., Tolias, P. & Manseau, L. (1999) Spire contains actin binding domains and is related to ascidian posterior end mark-5., Development. 126, 5267-5274.

 
  EDInfo Biomedical Sciences Cytoskeletal Links Encyclopaedia of A.B.P.s The Amoebae Protozoology links Glossary of Amoeba terms   Maciver Lab Home