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A 205 kDa protein from vertebrate tissue culture cells that has homology to the gelsolin/villin family (Pestonjamasp et al, 1997 ) in the C-terminus but unexpectedly the strong actin-binding region is apparently contained within the N-terminus (Wulfkuhle et al, 1999).  Supervillin was first detected in neutrophils where it is a very minor component but it is expressed in muscle in large amounts (  Supervillin was first detected in neutrophils where it is a very minor component but it is expressed in muscle in large amounts (Pope et al, 1998).  It is similar in size and in that it has multiple predicted nuclear targeting sequences to Afadin, but these are otherwise distinct proteins at the sequence level.  Supervillin associates with the androgen receptor and modulates its transcriptional activity in muscle cells (Ting et al, 2002).
Supervillin is associated with cholesterol rich detergent resistant membrane domain (DRMs) (see Lipid Rafts), along with myosin IG and myosin-IIA (
Nebl et al, 2002).  In addition, supervillin is associated with a complex including P2X7 receptor and signalling compoents (Kim et al, 2001).  Another indication that supervillin may be involved in signalling comes from studies in the signalling of pathogenic bacteria with host cells where supervillin mRNA is increased (Morozumi et al, 2001).


Domain stricture of Supervillin


  The Gelsolin Family



Kim, M., Jiang, L.-H., Wilson, H. L., North, R. A. & Surprenant, A. (2001) Proteomic and functional evidence for a P2X7 receptor signalling complex, EMBOJ. 20, 6347-6358.

Pestonjamasp, K. N., Pope, R. K., Wulfkuhle, J. D. & Luna, E. J. (1997) Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily, J.Cell Biol. 139, 1228-1253.

Pope, R. K., Pestonjamasp, K. N., Smith, K. P., Wulfkuhle, J. D., Strassel, C. P., Lawrence, J. B. & Luna, E. J. (1998) Cloning, chacacterization, and chromosomal localization of human supervillin (SVIL). Genomics. 52, 342-351.

Morozuami, T., Kubota, T., Sugita, N., Ohsawa, Y., Yamazaki, K. & Yoshie, H. (2001) Elevated mRNA expression for supervillin and vascular endothelial growth factor in human neutrophils stimulated with lipopolysaccharide from Porphyromonas gingivalis. J. Periodont. Res. 36, 160-168.

Nebl, T., Pestonjamasp, K. N., Leszyk, J. D., Crowley, J. L., Oh, S. W. & Luna, E. J. (2002) Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes, J. Biol. Chem.,(in press).

Ting, H.-J., Yeh, S., Nishimura, K. & Chang, C. (2002) Supervillin associates with androgen receptor and modulates its transcriptional activity., PNAS. 99, 661-666.

Wulfkuhle, J. D., Donina, I. E., Stark, N. H., Pope, R. K., Pestonjamasp, K. N., Niswonger, M. L. & Luna, E. J. (1999) Domain analyis of supervillin, an F-actin bundling plasma membrane protein with functional nuclear localization signals., J.Cell Sci. 112, 2125-2136.

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