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A 100 kDa heat-stable protein enriched in brain and kidney. It has a very high (~20%) proline content and two PPXY putative WW domain binding motifs.  The association of synaptospondin with actin is not known to be direct but the protein requires 0.5M NaCl to become free of the actin rich cell pellet and co-localises with F-actin by immunocytochemistry in a cytochalasin-sensitive manner (Mundel et al, 1997).  Another, related protein (Leinweber et al, 1999) expressed in smooth muscle, fesselin is a known actin-binding protein (Beall et al, 2001).  


Beall, B. & Chalovich, J. M. (2001) Fesselin, a synaptopodin-like protein, stimulates actin nucleation and polymerization., Biochemistry. 40, 14252-14259.

Leinweber, B. D., Fredrickson, R. S., Hoffman, D. R. & Chalovich, J. M. (1999) J.Muscle Res. Cell Motil. 20, 539-545.

Mundel, P., Heid, H. W., Mundel, T. M., Kruger, M., Reiser, J. & Kriz, W. (1997) Synaptopodin: An actin-associated protein in telencephalic dendrites and renal podocytes., JCB. 139, 193-204.

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