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Tensin

Page updated 7th March '04

Tensin is a c220kDa protein that is concentrated at the focal adhesion (Lo, 2004).  Tensin contains three distinct actin-binding sites (Lo et al, 1994), and caps the barbed end in a manner that permits the insertion of actin monomers on the capped end (Ruhnau et al, 1989; Weight et al, 1992). This is similar to the situation as the formins
 

 

References:-

Bockholt, S. M. & Burridge, K. (1993) Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin., J.Biol.Chem. 268, 14565-14567.

Lo, S. H., Janmey, P. A., Hartwig, J. H. & Chen, L. B. (1994) Interaction of tensin with actin and identification of its three distinct actin-binding domains., J.Cell Biol. 125, 1067-1075.

Lo, S.-H. (2004) Tensin. Int.J.Biochem.& Cell Biol. 36, 31-34.

Ruhnau, K., Gaertner, A. & Wegner, A. (1989) Kinetic evidence for insertion of actin monomers between the barbed ends of actin filaments and barbed end-bound insertin, a protein purified from smooth muscle. J.Mol.Biol. 210, 141-148.

Weight, C., Gaertner, A., Wegner, A., Korte, H. & Meyer, H. E. (1992) Occurrence of an actin-inserting domain in tensin. J Mol.Biol. 227, 593-595.

 

 
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