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A complex of three troponins, troponin C, troponin I and troponin T regulate the interactions between the thin (actin) and thick filament (myosin) systems during muscle contraction by moving tropomyosin from between the two.  This is under the tight regulation of calcium working through troponin C (a calmodulin related protein), both the other troponins (I and T) in the complex bind actin.  


Al-Hillawi, E., D. G. Bhandari, et al. (1995). “The effects of phosphorlyation of caridiac troponin-I on its interactions with actin and cardiac troponin-C.” Eur.J.Biochem. 228, 962-970.

Oliveira, D.M., Nakaie, C.R., Sousa, A.D., Farah, C.S. and Reinach, F.C. (2000). "Mapping the domain of troponin T responsible for the activation of actomyosin ATPase activity. Identification of residues involved in binding to actin." J.Biol.Chem. 275(36), 27513-27519.

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