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Tubulin (bIV-tubulin)

Tubulins are abundant proteins in eukaryotes, especially in vertebrate brain.  Two main sub types exist a and b, these form stable dimer complexes that polymerise to form microtubules.   Microtubules are frequently seen to associate and co-align with actin filaments and bundles in cells.  Several proteins that bind both microtubules and actin microfilaments (e.g. EF-1a, MAPs).  Recently a subtype of b-tubulin, bIV-tubulin has been discovered to be an actin-binding protein .

References:-

Walss-Bass, C., Prasad, V., Kreisberg, J. I. & Luduena, R. F. (2001) Interaction of the bIV-tubulin isotype with actin stress fibers in cultured rat kidney mesangial cells., Cell Motility Cytoskeleton. 49, 200-207.

 
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