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A protein of the focal adhesion.


Adey, N. B. & Kay, B. K. (1997) Isolation of peptides from phage-displayed random peptide libraries that interact with the talin-binding domain of vinculin, Biochem. J. 324, 523-528.

Alatortsev, V. E., Kramerova, I. A., Frolov, M. V., Lavrov, S. A. & Westphal, E. D. (1997) Vinculin gene is non-essential in Drosophila melanogaster, FEBS letters. 413, 197-801.

Avnur, Z., Small, J. V. & Geiger, B. (1983) Actin-dependent association of vinculin with the cytoplasmic aspect of the membrane in cell-contact areas, J.Cell Biol. 96, 1622-1630.

Bakolitsa, C., de Pereda, J. M., Bagshaw, C. R., Critchley, D. R. & Liddington, R. C. (1999) Crystal structure of the vinculin tail suggests a pathway for activation, Cell. 99, 603-613.

Belkin, A. M. & Koteliansky, V. E. (1987) Interaction of iodinated vinculin, metavinculin and a-actinin with cytoskeletal proteins, FEBS letters. 220, 291-294.

Bershadsky, A. D., Glück, U., Denisenko, O. N., Sklyarova, T. V., Spector, I. & Ben-Ze'ev, A. (1995) The state of actin assembly regulates actin and vinculin expression by a feedback loop, J. Cell Sci. 108, 1183-1193.

Bourdet-Sicard, R., Rüdiger, M., Jockusch, B., Gounon, P., Sansonetti, P. J. & Van Nhieu, G. T. (1999) Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization, EMBO J. 18, 5853-5862.

Brindle, N. P. J., Holt, M. R., Davies, J. E., Price, C. J. & Critchley, D. R. (1996) The focal-adhesion vasodilator-stimulated phosphoprotein (VASP) binds to the proline-rich domain in vinculin., Biochem. J. 318, 753-757.

Bubeck, P., Pistor, S., Wehland, J. & Jockusch, B. M. (1997) Ligand recruitment by vinculin domains in transfected cells, J.Cell Sci. 110, 1361-1371.

Byrne, B., Kaczorowski, Y., Coutu, M. & Craig, S. (1992) Chicken vinculin and meta-vinculin are derived from a single gene by alternative splicing of a 207-base pair exon unique to meta-vinculin., J. Biol. Chem. 267, 12845-12850.

Chevrier, V., Paintrand, M., Koteliansky, V., Block, M. R. & Job, D. (1995) Identification of vinculin as a pericentriolar component in mammalian cells, Exp.Cell Res. 219, 399-406.

Crenshaw, H. C., Allen, J. A., Skeen, V., Harris, A. & Salmon, E. D. (1996) Hydrostatic pressure has different effects on the assembly of tubulin, actin, myosinII, vinculin, talin, vimentin, and cytokeratin in mammalian tissue cells., Exp.Cell Res. 227, 285-297.

DePasquale, J. A. & Izzard, C. S. (1987) Evidence for an actin-containing cytoplasmic precursor of the focal contact and the timing of incorporation of vinculin at the focal contact, J.Cell Biol. 105, 2803-2809.

Domann, E., Wehland, J., Rohde, M., Pistor, S., Hartl, M., Goebel, W., Leimeister-Wachter, M., Wuenscher, M. & Chakraborty, T. (1992) A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin, EMBO Journal. 11, 1981-1990.

Drenckhahn, D. & Wagner, H.-J. (1985) Relation of retinomotor responses and contractile proteins in vertebrate retinas, Eur.J.Cell Biol. 37, 156-168.

Duband, J. L. & Thiery, J. P. (1990) Spatial and temporal distribution of vinculin and talin in migrating avian neural crest cells and their derivatives., Development. 108, 421-433.

Eimer, W., Niermann, M., Eppe, M. A. & Jockusch, B. M. (1993) Molecular shape of vinculin in aqueous solution, J.Mol.Biol. 229, 146-152.

Fausser, J.-L., Ungelwickell, E., Ruch, J.-V. & Lesot, H. (1993) Interaction of vinculin with the clatherin heavy chain, J.Biochem. 114, 498-503.

Fukami, K., Endo, T., Imamura, M. & Takenawa, T. (1994) a-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase, J. Biol. Chem. 269, 1518-1522.

Gilmore, A. & Burridge, K. (1996) Regulation of vinculin binsinf to talin and actin by phosphatidyl-inositol-4-5-bisphosphate, Nature. 381, 531-535.

Gilmore, A., Jackson, P., Waites, G. & Critchley, D. (1992) Further characterization of the talin-binding site in the cytoskeletal protein vinculin., J. Cell Sci. 103, 719-731.

Gilmore, A. P., Wood, C., Ohanian, V., Jackson, P., Patel, B., Rees, D. J. G., Hynes, R. O. & Critchley, D. R. (1992) The cytoskeletal protein talin contains at least 2 distinct vinculin binding domains., J. Cell Biol. 122, 337-347.

Gimona, M., Small, J. V., Moeremans, M., Van Damme, J., Purype, M. & Vandekerckhove, J. (1988) Porcine vinculin and metavinculin differ by a 68-residue insert located close to the carboxy-terminal part of the molecule, EMBO J. 7, 2329-2334.

Goldberg, M. B. (1997) Shigella actin-based motility in the absence of vinculin, Cell Mot.Cytoskel. 37, 44-53.

Goldmann, W. H., Niggli, V., Kaufmann, S. & Isenberg, G. (1992) Probing actin and liposome interaction of talin and talin-vinculin complexes: a kinetic, thermodynamic and lipid labeling study, Biochemistry. 31, 7665-7671.

Goldmann, W. H., Schindl, M., Cardozo, T. J. & Ezzel, R. M. (1995) Motility of vinculin-deficient F9 embryonic carcinoma cells analyzed by video, laser confocal, and reflection interference contrast microscopy, Exp.Cell Res. 221, 311-319.

Goldmann, W. H., Senger, R., Kafmann, S. & Isenberg, G. (1995) Determination of the affinity of talin and vinculin to charged lipid vesicles: a light scatter study, FEBS letters. 368, 516-518.

Götter, R., Goldmann, W. H. & Isenberg, G. (1995) Internal actin filament dynamics in the presence of vinculin: a dynamic light scattering study, FEBS letters. 359, 220-222.

Hagmann, J. (1993) Pattern formation and handedness in the cytoskeleton of human platelets, Proc. Natl. Acad. Sci. USA. 90, 3280-3283.

Hemmings, L., Rees, D. L. G., Ohanian, V., Bolton, S. J., Gilmore, A. P., Patel, B., Priddle, H., Trevithick, J. E., Hynes, R. O. & Critchley, D. R. (1996) Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site, J.Cell Sci. 109, 2715-2726.

Hirsch, M. S. & Svlboda, K. (1994) Intracellular-localization of vinculin and gelsolin in embryonic avian corneal epithelia, Investigative Ophthalmology & Visual Science. 35, 1940.

Hüttelmaier, S., Bubeck, P., Rüdiger, M. & Jockusch, B. M. (1997) Characterization of two F-actin-binding and oligomerization sites in the cell-contact protein vinculin, Eur.J.Biochem. 247, 1136-1142.

Hüttelmaier, S., Mayboroda, O., Harbeck, B., Jarchau, T., Jockusch, B. M. & Rüdiger, M. (1998) The interaction of cell-contact proteins VASP and vinculin is regulated by phosphatidylinositol-4,5-bisphosphate, Current Biol. 8, 479-488.

Jockusch, B. M. & Rüdiger, M. (1996) Crosstalk between cell adhesion molecules: vinculin as a paradigm for regulation by conformation, Trends Cell Biol. 6, 311-315.

Johnson, R. & Craig, S. (1994) An intramolecular association between the head and tail domains of vinculin modulates talin binding., J. Biol. Chem. 269, 12611-12619.

Johnson, R. & Craig, S. (1995) F-actin binding site masked by the intramolecular association of vinculin head and tail domains., Nature. 373, 261-264.

Johnson, R. P. & Craig, S. W. (1995) The carboxy-terminal tail domain of vinculin contains a cryptic binding site for acidic phospholipids, Biochem.Biophys.Res.Comm. 210, 159-164.

 Johnson, R. P. & Craig, S. W. (2000) Actin activates a cryptic dimerization potential of the vinculin tail domain, J.Biol.Chem. 275, 95-105.

Korneeva, N. & Jockusch, B. M. (1996) Light microscopic analysis of ligand-induced actin filament suprastructures, Eur.J. Cell Biol. 71, 351-355.

Lee, S.-W. & Otto, J. J. (1996) Differences in turnover rates of vinculin and talin caused by viral transformation and cell density, Exp.Cell Res. 227, 352-359.

Lee, S.-W. & Otto, J. T. (1997) Vinculin and talin: kinetics of entry and exit from the cytoskeletal pool, Cell Mot.Cytoskeleton. 36, 101-111.

Lee, T.-Y. J. L. & Gotlieb, A. I. (1999) Early stages of endothelial wound repair: conversion of quiescent to migrating endothelial cells involves tyrosine phosphorylation and actin microfilament reorganization., Cell Tiss.Res. 297, 435-450.

McGregor, A., Blanchard, A. D., Rowe, A. J. & Critchley, D. R. (1994) Identification of the vinculin-binding site in the cytoskeletal protein a-actinin, Biochem. J. 301, 225-233.

Menkel, A. R., Kroemker, M., Bubeck, P., Ronsiek, M., Nikolai, G. & Jockusch, B. M. (1994) Characterization of an F-actin-binding domain in the cytoskeletal protein vinculin, J. Cell Biol. 126, 1231-1240.

Moulder, G. L., Huang, M. M., Waterston, R. H. & Barstead, R. J. (1996) Talin requires b-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans, Mol.Biol.Cell. 7, 1181-1193.

Opas, M., Szewczenko-Pawlikowski, M., Jass, G. K., Mesaeli, N. & Michalak, M. (1996) Calreticulin modulates cell adhesiveness via regulation of vinculin expression, J.Cell Biol. 135, 1913-1923.

Rodríguez-Fernández, J. L., Geiger, B., Salomon, D. & Ben-Ze'ev, A. (1992) Overexpression of vinculin suppresses cell motility in BALB/c 3T3 cells, Cell Mot.Cytoskel. 22, 127-134.

Rodríguez-Fernández, J. L., Geiger, B., Salomon, D. & Ben-Ze'ev, A. (1993) Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells, J.Cell Biol. 122, 1285-1294.

Rĝnnov-Jessen, L. & Petersen, O. W. (1996) A function for filamentous a-smooth muscle actin: Retardation of motility in fibroblasts, J.Cell Biol. 134, 67-80.

Rottner, K., Krause, M., Gimona, M., Small, J. V. & Wehland, J. (2001) Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellopodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions., Mol.Biol.Cell. 12, 3103-3113.

Ruddies, R., Goldmann, W. H., Isenberg, G. & Sackmann, E. (1993) The viscoelasticity of entangled actin networks: the influence of defects and modulation by talin and vinculin, Eur.Biophys.J. 22, 309-321.

Rüdiger, M. (1998) Vinculin and a-actinin: shared and unique functions in adherens junctions, BioEssays. 20, 733-740.

Samuels, M., Ezzel, R. M., Cardozo, T. J., Critchley, D. R., Coll, J.-L. & Adamson, E. D. (1993) Expression of chicken vinculin complements the adhesion-defective phenotype of a mutant mouse F9 embryonic carcinoma cell, J.Cell Biol. 121, 909-921.

Steimle, P. A., Hoffert, J. D., Adey, N. B. & Craig, S. W. (1999) Polyphosphoinositides inhibit the interaction of vinculin with actin filaments., J.Biol.Chem. 274, 18414-18420.

Strasser, P., Gimona, M., Herzog, M., Geiger, B. & Small, J. V. (1993) Variable and constant regions in the C-terminus of vinculin and metavinculin, FEBS letters. 317, 189-194.

Suzuki, T., Saga, S. & Sasakawa, C. (1996) Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility, J.Biol.Chem. 271, 21878-21885.

Tempel, M., Goldmann, W. H., Isenberg, G. & Sackmann, E. (1995) Interaction of the 47-kDa talin fragment and the 32-kDa vinculin fragment with acidic phospholipids: a computer analysis, Biophys.J. 69, 228-241.

Tran Van Nhieu, G., Ben-Ze'ev, A. & Sansonetti, P. J. (1997) Modulation of bacterial entry inot epithelial cells by association between vinculin and the Shigella IpaA invasin, EMBO J. 16, 2717-2729.

Varnum-Finney, B. & Reichardt, L. F. (1994) Vinculin-deficient PC12 cell lines extend unstable lamellipodia and filopodia and have reduced rate of neurite outgrowths, J.Cell Biol. 127, 1071-1084.

Wachsstock, D. H., Wilkins, J. A. & Lin, S. (1987) Specific interaction of vinculin with a-actinin, Biochem.Biophys.Res.Comm. 146, 554-560.

Wood, C. K., Turner, C. E., Jackson, P. & Critchley, D. R. (1994) Characterisation of the paxillin-binding site and the C-terminal focal adhesion targeting sequence in vinculin, J. Cell Sci. 107, 709-717.

Yürüker, B. & Niggli, V. (1992) a-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network, J.Cell Sci. 101, 403-414.

Ziegler, W. H., Tigges, U., Zieneniss, A. & Jockusch, B. M. (2002) A lipid-regulated docking site on vinculin for protein kinase C., J.Biol.Chem. 277, 7396-7404.

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