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Wiskott-Aldrich Syndrome Protein (WASP)

The gene encoding this protein was discovered to be mutated in hereditary disease Wiskott-Aldrich that has given the gene and its protein the name.  


Abdul-Manan, N., Aghazadeh, B., Liu, G.A., Majumdar, A., Ouerfelli, O., Siminovitch, K.A. & Rosen, M.K.(1999). "Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein." Nature 399, 379-383.

Bi, E. & Zigmond, S.H. (1999). "Actin polymerization: where the WASP stings." Curr.Biol. 9, R160-R163.

Castellano, F., Montcourrier, P., Guillemot, J.C., Gouin, E., Machesky, L., Cossart, P. & Chavrier, P. (1999). "Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation." Curr.Biol. 9, 351-360.

Kato, M., Mik, H., Imai, K., Nonoyama, S., Suzuki, T., Sasakawa, C. & Takenawa, T. (1999). "Wiskott-Aldrich syndrome protein induces actin clustering without direct binding to Cdc42." J.Biol.Chem. 274, 27225-27230.

Linder, S., Nelson, D., Weiss, M. & Aepfelbacher, M. (1999). "Wiskott-Alsrich syndrome protein regulates podosomes in primary human macrophages. PNAS USA 96, 9648-9653.

Li, R., Debreceni, B., Jia, B., Gao, Y., Tigyi, G. & Zheng, Y. (1999). "Localization of the PAK1-, WASP-, and IQGAP1-specifying regions of Cdc42." J.Biol.Chem. 274(42), 29648-29654.

Moreau, V., Frischknecht, F., Reckman, I., Vincentelli, R., Rabut, G., Stewart, D. & Way, M. (2000). " A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization." Nature Cell Biol. 2, 441-448.

Mott, H.R., Owen, D., Nietlispach, D., Lowe, P.N., Manser, E., Lim, L. & Laue, E.D. (1999). "Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK." Nature 399, 384-388.

O'Sullivan, E., Kinnon, C. & Brickell, P. (1999). "Wiskott-Aldrich syndrome protein, WASP." Int.J.Biochem.Cell Biol. 31, 383-387.

Ramesh, N., Anton, I.M., Hartwig, J.H. & Geha, R.S. (1997). "WIP, a protein associated with Wiskott-Aldrich syndrome protein, induce actin polymerization and redistribution in lymphoid cells." PNAS USA 94, 14671-14676.

Ramesh, N., Anton, I.M., Martinez-Quiles, N. & Geha, R.S. (1999). "Waltzing with WASP." Trends Cell Biol. 9, 15-19.

Rozelle, A.L., Machesky, L.M., Yamamoto, M., Driessens, M.H.E., Insall, R.H., Roth, M.G., Luby-Phelps, K., Marriot, G., Hall, A. & Yin, H.L. (2000). "Phosphatidyinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3." Curr.Biol. 10, 311-320.

Tian, L., Nelson, D.L. & Stewart, D.M. (2000). " Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules. J.Biol.Chem. 275(11), 7854-7861.

Yarar, D., To, W., Abo, A. & Welch, M.D. (1999). "The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex." Curr. Biol. 9, 555-558.

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