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Membrane Rafts & The Cytoskeleton

Singer's famous "Fluid Mosaic" model (Singer, 19) of the biological membrane was very nearly 100% correct with two minor corrections.  One was that he had hypothesized the existence of proteins that crossed half way through the lipid bilayer (Figure 1), the other was that  lipid components are far from randomly and evenly distributed as his paper suggested.  
References:-

Brdickova, N., Brdicka, T., Andrea, L., Spicka, J., Angelisova, P., Milgram, S. L. & Horejsi, V. (2001) Interaction between two adaptor proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton., FEBS letters. 507, 133-136.

Cary, L. A. & Cooper, J. A. (2000) Molecular switches in lipid rafts., Nature. 404, 945-947.

Gomez-Mouton, C., Abad, J. L., Mira, E., Lacalle, R. A., Gallardo, E., Jimenez-Baranda, S., Illa, I., Bernad, A., Manes, S. & Martinez-A, C. (2001) Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization., PNAS. 98, 9642-9647.

Jacobson, K. & Dietrich, C. (1999) Looking at lipid rafts?, Trends Cell Biol. 9, 87-91.

Seveau, S., Eddy, R. J., Maxfield, F. R. & Pierini, L. M. (2001) Cytoskeleton-dependent membrane domain segregation during neutrophil polarization., Mol. Biol. of the Cell. 12, 3550-3562.

Sowa, G., Pypaert, M. & Sessa, W. C. (2001) Distinction between signaling mechanisms in lipid rafts vs. caveolae., PNAS. 98, 14072-14077.

Singer

Villalba, M., Bi, K., Rodriguez, F., Tanaka, Y., Schoenberger, S. & Altman, A. (2001) Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells., J.Cell Biol. 155, 331-338.

 
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